Plasminogen: The Clot Buster

Buster

Dual frequency ultrasound-enhanced tissue plasminogen activator thrombolysis in an in vitro human clot model

Introduction: Stroke causes death and disability in patients throughout the world. At present, the only FDA- approved drug for ischemic stroke is recombinant tissue plasminogen activator (rt- PA). Unfortunately, rtPA can cause intracerebral hemorrhage and must use within limited time window (within 3-4.5 hour after onset of stroke). Ultrasound with rtPA loaded liposomes (rtPA_L...

Tissue plasminogen activator-based clot busting: Controlled delivery approaches

Cardiovascular diseases are the leading cause of death worldwide. Thrombosis, the formation of blood clot (thrombus) in the circulatory system obstructing the blood flow, is one of the main causes behind various ischemic arterial syndromes such as ischemic stroke and myocardial infarction, as well as vein syndromes such as deep vein thrombosis, and consequently, pulmonary emboli. Several thromb...

Tissue plasminogen activator and seizures: a clot-buster's secret life.

Seizures, caused by hypersynchronized electrical activity, can occur when an area of the brain becomes injured as a result of various pathologies such as degenerative disorders, brain tumors, or head trauma. Seizures are an extremely widespread problem, with about 10% of the population experiencing them at least once in their lives. They are hazardous both because of the uncontrolled motor acti...

Fingerprint Spoof Buster

The primary purpose of a fingerprint recognition system is to ensure a reliable and accurate user authentication, but the security of the recognition system itself can be jeopardized by spoof attacks. This study addresses the problem of developing accurate, generalizable, and efficient algorithms for detecting fingerprint spoof attacks. Specifically, we propose a deep convolutional neural netwo...